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Rather than relying only on calorie restriction or exercise, these medications target the biological mechanisms that regulate appetite, satiety, and blood sugar

mGSH decreases up to 50% with age [145,146], being more marked in male than female mice in many tissues

In two specific studies, the effects of GLP-1RA on gastric emptying diminished with prolonged use, a concept termed tachyphylaxis (25, 26)

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